LVOT Obstruction
CAMZYOS Significantly Reduced LVOT Obstruction vs Placebo1,2
Mean change in post-exercise LVOT peak gradient from baseline to Week 301,2
LVOT obstruction was assessed by post-exercise LVOT peak gradient.
Treatment difference (95% CI): -35 mmHg (-43, -28);
P<0.0001
Guideline-based threshold for surgery consideration (>50 mmHg)2
Guideline-based diagnostic criteria for obstruction (>30 mmHg)2
Data based on all randomized patients who received ≥1 dose of study treatment. LVOT gradient was analyzed with all available data without imputation.2
Exploratory endpoints: proportion of patients achieving post-exercise LVOT peak gradient <50 mmHg or <30 mmHg at Week 301,2
While these exploratory endpoints were prespecified, they were not powered for significance.3
74% (n=75/101) of patients on CAMZYOS had
a post-exercise LVOT gradient <50 mmHg
and 21% (n=22/106) in the placebo arm2*
57% (n=64/113) of patients on CAMZYOS had
a post-exercise LVOT gradient <30 mmHg
and 7% (n=8/114) in the placebo arm2†
- *Only patients with baseline post-exercise LVOT peak gradient of at least 50 mmHg were assessed.2
- †Only patients with baseline post-exercise LVOT peak gradient of at least 30 mmHg were assessed.2
LVOT=left ventricular outflow tract.